Preparative Organic Chemistry
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ChemInform Abstract: The Organoselenium-Mediated Reduction of α,β-Epoxy Ketones, α,β-Epoxy Esters, and Their Congeners to β-Hydroxy Carbonyl Compounds: Novel Methodologies for the Synthesis of Aldols and Their Analogues.
First published: 24 June 2010
Abstract
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ChemInform Abstract
The reduction of the title compounds with Na[PhSeB(OEt)3] (prepared by reduction of (PhSe)2 with NaBH4 in EtOH) and PhSeH (generated in situ from the borate complex with AcOH) leads regioselectively to β-hydroxy carbonyl compounds in good yields.
