ChemInform Abstract: Synthesis of Amides of 2-Substituted Cinchoninic Acids and Their Cyclization into Amides of 1,2,4-Triazolo[4,3-a]quinoline-9- and 1,2,4-Triazino[4,3-a]quinoline-10 Carboxylic Acids.
Abstract
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ChemInform Abstract
The 2-hydrazinocinchoninic acid amides (I) are used for several anellation reactions. Thus, the reaction with pyruvic acid (II) gives the triazinoquinolines (III) while with the corresponding ethyl pyruvates (IV) open-chain hydrazones (V) are formed which cyclize only during heating. The reaction with ethyl othoformate or aldehydes leads to the corresponding triazoloquinolines (VII) and (IX), respectively.
