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ChemInform Abstract: Asymmetric Total Syntheses of (+)-Coronafacic Acid and (+)-Coronatine, Phytotoxins Isolated from Pseudomonas syringae Pathovars.
First published: 02 August 2010
Abstract
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ChemInform Abstract
The key steps in the synthesis of the title acid (X) are asymmetric addition of the diester (II) to the enone (I) and diastereoselective cyclization of the ketone (VII). Coupling of (X) with the amino ester ( XI) and subsequent deprotection yields (+)-coronatine (XII).
