Heterocyclic Compounds
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ChemInform Abstract: Facile Synthesis of β-Hydroxy-δ-valerolactone via the Ring Opening Reaction of β-Trichloromethyl-β-propiolactone with Ester Enolates.
First published: 02 August 2010
Abstract
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ChemInform Abstract
Key steps in the synthesis of the title compound (V) are the syn- selective reduction of ketone (III) and the subsequent cyclization. Compound (VII) is an excellent precursor for the synthesis of compactin and mevinolin derivatives.
