ChemInform Abstract: Batrachotoxin Binding Site Antagonists.

S. R. SCHOW,

S. R. SCHOW

Biol. Chem. Group., E. I. du Pont Nemours Co., Exp. Stn., Wilmington, DE 19898, USA

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D. P. ROSSIGNOL,

D. P. ROSSIGNOL

Biol. Chem. Group., E. I. du Pont Nemours Co., Exp. Stn., Wilmington, DE 19898, USA

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A. E. LUND,

A. E. LUND

Biol. Chem. Group., E. I. du Pont Nemours Co., Exp. Stn., Wilmington, DE 19898, USA

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M. E. SCHNEE,

M. E. SCHNEE

Biol. Chem. Group., E. I. du Pont Nemours Co., Exp. Stn., Wilmington, DE 19898, USA

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S. R. SCHOW,

S. R. SCHOW

Biol. Chem. Group., E. I. du Pont Nemours Co., Exp. Stn., Wilmington, DE 19898, USA

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D. P. ROSSIGNOL,

D. P. ROSSIGNOL

Biol. Chem. Group., E. I. du Pont Nemours Co., Exp. Stn., Wilmington, DE 19898, USA

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A. E. LUND,

A. E. LUND

Biol. Chem. Group., E. I. du Pont Nemours Co., Exp. Stn., Wilmington, DE 19898, USA

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M. E. SCHNEE,

M. E. SCHNEE

Biol. Chem. Group., E. I. du Pont Nemours Co., Exp. Stn., Wilmington, DE 19898, USA

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First published: 04 August 2010

https://doi.org/10.1002/chin.199720189

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Abstract

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ChemInform Abstract

The class of sodium ion channel neurotoxins is investigated. The necessity of the oxygen triad, heteroatom and lipophilic moiety is examined by preparing and evaluating a number of potential pharmacophore representatives. The batrachotoxin partial structures ( VII), (IX), and (XIV) which display the key molecular features of the class II channel toxins, are prepared as pharmacophore targets to probe for potential batrachotoxin activity. Analogue (XIV) demonstrates the highest levels of antagonist activity.