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ChemInform Abstract: 2,3-Substituted 2-Azanorbornanes as Polar β-Turn Mimetics.
First published: 04 August 2010
Abstract
ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract
The conformationally restrained Trp-Phe mimetic (X) is constructed which is designed to mimic the size and direction of the dipole moment as well as the orientation of the two central amino acid side chains in a β-turn. The tachykinin receptor affinities of (X) are evaluated and compared to those of the NK-2 antagonist MEN 10627.
