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ChemInform Abstract: Efficient and Diastereoselective Synthesis of (+)-Goniobutenolide A via Palladium-Catalyzed Ene-Yne Cross Coupling-Lactonization Cascade.
First published: 04 August 2010
Abstract
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ChemInform Abstract
The diastereoselective synthesis of the marginally antitumor (+)- goniobutenolide A (X) is based on the Pd-catalyzed reaction of the terminal acetylene (VI) with (Z)-3-bromopropenoic acid (VII) leading to the lactone with essentially complete control of the exocyclic alkene geometry.
