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ChemInform Abstract: Total Synthesis of Isodeoxypodophyllotoxin Using the Me3Sn Radical Initiated Carbocyclization.
First published: 04 August 2010
Abstract
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ChemInform Abstract
The synthesis of the racemic title compound (XV) uses a trimethylstannyl radical addition to a dienic system for the construction of the lactone portion of the podophylotoxin framework as the key step. Both alcohols (VII) and (VIII) afford the desired product by intramolecular Friedel-Crafts reaction.
