Volume 28, Issue 13
Natural Products
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ChemInform Abstract: The Staurosporine Producing Strain Streptomyces longisporoflavus Produces Metabolites Related to K-252a. Proposal for Biosynthetic Intermediates of K-252a.

Y. CAI

Y. CAI

Core Drug Discovery Technol., Pharm. Res., CIBA-GEIGY Ltd., CH-4002 Basel, Switz.

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A. FREDENHAGEN

A. FREDENHAGEN

Core Drug Discovery Technol., Pharm. Res., CIBA-GEIGY Ltd., CH-4002 Basel, Switz.

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P. HUG

P. HUG

Core Drug Discovery Technol., Pharm. Res., CIBA-GEIGY Ltd., CH-4002 Basel, Switz.

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H. H. PETER

H. H. PETER

Core Drug Discovery Technol., Pharm. Res., CIBA-GEIGY Ltd., CH-4002 Basel, Switz.

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First published: 04 August 2010

Abstract

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ChemInform Abstract

Based on the rather surprising result that the title strain produces K- 252a and compound (II) as minor metabolite a pathway for the last two steps in the biosynthesis of K-252a is proposed.

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