Preparative Organic Chemistry
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ChemInform Abstract: Synthesis of Allylic Trifluoromethyl Alcohols from 1-Trifluoromethyl- epoxy Ethers.
First published: 04 August 2010
Abstract
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ChemInform Abstract
A simple convenient and high-yielding 3-step synthesis of E- configurated allylic trifluoromethyl alcohols (IV) is presented, which is suitable for large-scale preparations. Key step is the regioselective opening of epoxides (I) followed by a stereoselective in situ reduction leading to the syn isomers (III) as the major products.
