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ChemInform Abstract: Design and Comprehensive Conformational Studies of Tyr1-cyclo(D-Pen2- Gly3-Phe4-L-3-Mpt5) and Tyr1-cyclo(D-Pen2-Gly3-Phe4-D-3-Mpt5): Novel Conformationally Constrained Opioid Peptides.
First published: June 4, 1996
Abstract
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ChemInform Abstract
Employing energy calculations the two title compounds are designed and their structures studied by homo- and heteronuclear NMR spectroscopy and X-ray analysis. The compounds are tested for their binding to . delta.-, μ-, and ϰ-opioid receptors. The solution conformations are compared to their suggested δ-receptor-bound conformers.
