ChemInform Abstract: Synthesis of Estimated Metabolites of 9-Amino-2,3,5,6,7,8-hexahydro-1H- cyclopenta(b)quinoline Monohydrochloride Monohydrate (NIK-247). Part 1. Synthesis of Monohydroxylated Metabolites.
Abstract
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ChemInform Abstract
Reduction of the two tricyclic ketones (I) and (III) affords the racemic alcohols (II) and (IV), respectively. Optical resolution of each alcohol using (+)-di-p-toluoyl-D-tartaric acid leads to the corresponding optically active metabolites in 100% e.e.