ChemInform Abstract: Synthesis of Bispiroheterocyclic Systems as Antimicrobial Agents via the Reaction of 2-(Cycloalkylidene)-1-thia-4-azaspiro(4.4)nonan-3-one and/or (4.5)Decan-3-one with Hydrazines, Hydroxylamine, Urea and Thiourea Derivatives.
Abstract
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ChemInform Abstract
Thirteen title compounds (20 examples) are tested in comparison with the reference compound tetracycline. They do not show antimicrobial activities except some activities of (IIb) and (IIc) against Escherichia coli and of (V) and (VIIa) against Staphylococcus aureus.