Heterocyclic Compounds
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ChemInform Abstract: Preparation of 3-(4-Pyridinylamino)-1,2-benzisoxazoles via a Nucleophilic Aromatic Substitution Reaction.
First published: June 4, 1996
Abstract
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ChemInform Abstract
In connection with a program directed towards the discovery of new Alzheimer′s disease therapeutics an efficient three-step process for the preparation of secondary 3-amino-1,2-benzisoxazoles (III) is reported. The key step is the final isomerization/cyclization of amidoxime (II).
