ChemInform Abstract: Double Ring Expansions: A New Method for Making Medium and Large Cyclic Ketones.
Abstract
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ChemInform Abstract
Large cyclic ketones such as (V), (VI), and (VII) are prepared by a free radical ring expansion of the cyclobutenones (I) followed by fluoride-induced Grob fragmentation of (IV). The cyclobutenones, e.g. ( Ic), are easily obtained by a (2 + 2) cycloaddition of bromoalkylketenes to cyclic enol ethers such as (VIII).