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ChemInform Abstract: Substitution of the Methyl Groups with Ethyl Groups at C-10 and C-15 of 2,3-Oxidosqualene Halts the Enzymatic Reaction of Oxidosqualene- Lanosterol Cyclase at the Monocyclic Ring Stage.
First published: April 30, 1996
Abstract
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ChemInform Abstract
The cyclization of 40 mg of the oxidosqualene (I) stops at the stage of monocyclic compounds giving 4 mg of (-)-(II) and 5 mg of (+)-(III) after 45% conversion based on one enantiomer of the racemic (I). No conversion is observed with cyclase derived from baker′s yeast. The influence of the title substituents is discussed.
