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ChemInform Abstract: Total Synthesis of Natural and ent-Fredericamycin A.
First published: April 16, 1996
Abstract
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ChemInform Abstract
Resolution of the penultimate precursor (.+-.)-(XIV) followed by deprotection provides natural fredericamycin A (R)-(XV) and ent- fredericamycin A of indistinguishable in vitro L1210 cytotoxic activity of IC50 0.03 and 0.04 μg/ml, respectively.
