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ChemInform Abstract: Synthesis and Biological Evaluation of Sulfamoyl Nucleosides Related to Carbovir and AZT.
First published: April 16, 1996
Abstract
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ChemInform Abstract
The synthesis of a number of 5′-O-sulfamoylated carbocyclic 2′,3′- dideoxy nucleosides related to carbovir (cf. (III)) and the sulfamoylated AZT-triphosphate analogue (VII) is given. Some of the synthesized nucleoside derivatives display significant in vitro anticancer activity.
