ChemInform Abstract: Saponaceolides: Differential Cytotoxicity and Enantioselective Synthesis of the Right-Hand Lactone Moiety.
Abstract
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ChemInform Abstract
The synthesis of right-hand moiety (XII) of the cytotoxic triterpene saponaceolide B is conducted via the iodide (III), obtained in 3 steps from commercially available (I) or in 8 steps from (S)-malic acid. The mean graph profiles of (XII) do not match the characteristic patterns of differential cytotoxicity of saponaceolides A and B in the NCI human disease-oriented tumor screening panel.
