Heterocyclic Compounds
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ChemInform Abstract: Asymmetric Synthesis of a Xanthine Dehydrogenase Inhibitor (S)-(-)-BOF- 4272 (VI): Utility of Chiral Alkoxysulfonium Salts.
First published: April 16, 1996
Abstract
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ChemInform Abstract
The title compound (VI) is prepared from (I) via the (S)-configurated sulfoxide (II) obtained with high e.e. (73%) or in enantiomerically pure form by varying methods. The intermediate (V) is transformed by thermolysis (retention) and hydrolysis (inversion) into (R)- and (S)-( II), respectively (some yields given in mg).
