Isocyclic Compounds
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ChemInform Abstract: Enantiocomplementary Routes to 6-Oxygenated (2Z,4E)-Alkadiene Precursors via Diastereoselective Reduction of 2-Cyclobuten-1-yl Ketones.
First published: April 16, 1996
Abstract
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ChemInform Abstract
The ketone (I) and the hydroxy analogue are reduced with a series of hydride reagents in order to get alcohol products of type (II)/(III) with high diastereoselectivity. The best result is obtained for (I) in the presence of LiAlH(O-tBu)3. The products are precursors of (2Z, 4E)-alkadienals, suitable synthons for biologically active molecules.
