Preparative Organic Chemistry
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ChemInform Abstract: Heterocyclizations of 3-Trifluoroacetyl-lactams with Ethylenediamine and 2-Aminoethanol.
First published: April 16, 1996
Abstract
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ChemInform Abstract
Condensations of 3-trifluoromethyl-lactams (I) with ethylenediamine and 2-aminoethanol occur exclusively on the trifluoroacetyl function of the lactams (I) without opening of the lactam structure furnishing imidazolines (III) or oxazolidine (V), respectively. Mechanistic aspects of the reaction are discussed.
