Preparative Organic Chemistry
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ChemInform Abstract: Optically Active Dihydropyridines via Lipase-Catalyzed Enantioselective Hydrolysis.
First published: April 16, 1996
Abstract
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ChemInform Abstract
Hydrolysis of the prochiral diesters (I) in the presence of Pseudomonas lipases K-10 and P-30 leads to the (R)-monoesters (II), whereas with the Candida cylindracea lipase OF-360 the (S)-monoesters ( II) are obtained. In contrast, the stereochemical outcome of the Pseudomonas lipase AK mediated hydrolysis is found to depend on the substituents.
