ChemInform Abstract: Further Studies on the anti-Selective Aldol Reaction of Chiral Imides.
Abstract
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ChemInform Abstract
During a study concerning the construction of the lankanolide framework, a synthetically useful boron-mediated anti-selective aldol condensation of the imide (I) with acetaldehyde (II) to give the desired synthon (III) (79% isolated yield) is reported. The method is complementary to existing Al-mediated processes. Additionally, tartaric acid is found to remove boron from the aldol condensation mixture without destruction of the aldolate.
