Volume 27, Issue 11
Preparative Organic Chemistry
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ChemInform Abstract: Stereocontrolled Synthesis of DTPA Analogues Branched in the Ethylene Unit.

C. W. GROTE

C. W. GROTE

Dep. Chem., Univ. Calif., Berkeley, CA 94720, USA

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D. J. KIM

D. J. KIM

Dep. Chem., Univ. Calif., Berkeley, CA 94720, USA

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H. RAPOPORT

H. RAPOPORT

Dep. Chem., Univ. Calif., Berkeley, CA 94720, USA

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First published: March 12, 1996

Abstract

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ChemInform Abstract

The synthesis of the title compounds (IX) and (XII) is achieved via coupling of the mixed anhydrides of the acids (VII) and (X) with the amine (VI). Interestingly, condensation of the phthaloyl protected alaninol (I) with amino acid esters leads to considerable amounts of oxazoloisoindoles as by-products.

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