ChemInform Abstract: Inhibitory Activities of Herpes Simplex Viruses Type 1 and 2 and Human Cytomegalovirus by Stereoisomers of 2′-Deoxy-3′-oxa-5(E)-(2-bromovinyl) uridines and Their 4′-Thio Analogues.
Abstract
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ChemInform Abstract
Two series of optically pure 2,4-disubstituted dioxolanes (III), (IV) and oxathiolane nucleosides (VI), (VII) (no yields given) containing bromovinyluracil are synthesized and assayed for activity against HSV- 1, HSV-2 and HCMV replication in vitro. The enantiomers of (III), (IV) and (VI), (VII) are prepared in an analogous manner. The deacetylated analogue of nucleoside (IV) displays significant activity against HSV- 1, whereas the desilylated analogue of oxathiolane (VI) demonstrates potent activity against HSV-2. Deacetylated (III) is moderately active against HSV-1.
