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ChemInform Abstract: Synthesis and Antiviral Activity of a Novel Class of HIV-1 Protease Inhibitors Containing a Heterocyclic P1′-P2′ Amide Bond Isostere.
First published: May 9, 1995
Abstract
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ChemInform Abstract
The introduction of heterocyclic ring systems as an amide bond isostere leads to peptidomimetics such as (VIII), (IX), and (XII) with the title biological activity. It is noteworthy that the incorporation of an imidazole leads to the most potent compounds in this series. Further structure-activity relationships are studied and discussed.
