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ChemInform Abstract: Acyclic NK-1 Antagonists: 2-Benzhydryl-2-aminoethyl Ethers.

B. J. WILLIAMS,

B. J. WILLIAMS

Dep. Med. Chem., Neurosci. Res. Cent., Merck Sharp and Dohme Res. Lab., Harlow, Essex CM20 2QR, UK

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M. TEALL,

M. TEALL

Dep. Med. Chem., Neurosci. Res. Cent., Merck Sharp and Dohme Res. Lab., Harlow, Essex CM20 2QR, UK

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J. MC KENNA,

J. MC KENNA

Dep. Med. Chem., Neurosci. Res. Cent., Merck Sharp and Dohme Res. Lab., Harlow, Essex CM20 2QR, UK

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T. HARRISON,

T. HARRISON

Dep. Med. Chem., Neurosci. Res. Cent., Merck Sharp and Dohme Res. Lab., Harlow, Essex CM20 2QR, UK

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C. J. SWAIN,

C. J. SWAIN

Dep. Med. Chem., Neurosci. Res. Cent., Merck Sharp and Dohme Res. Lab., Harlow, Essex CM20 2QR, UK

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M. A. CASCIERI,

M. A. CASCIERI

Dep. Med. Chem., Neurosci. Res. Cent., Merck Sharp and Dohme Res. Lab., Harlow, Essex CM20 2QR, UK

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S. SADOWSKI,

S. SADOWSKI

Dep. Med. Chem., Neurosci. Res. Cent., Merck Sharp and Dohme Res. Lab., Harlow, Essex CM20 2QR, UK

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C. STRADER,

C. STRADER

Dep. Med. Chem., Neurosci. Res. Cent., Merck Sharp and Dohme Res. Lab., Harlow, Essex CM20 2QR, UK

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R. BAKER,

R. BAKER

Dep. Med. Chem., Neurosci. Res. Cent., Merck Sharp and Dohme Res. Lab., Harlow, Essex CM20 2QR, UK

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B. J. WILLIAMS,

B. J. WILLIAMS

Dep. Med. Chem., Neurosci. Res. Cent., Merck Sharp and Dohme Res. Lab., Harlow, Essex CM20 2QR, UK

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M. TEALL,

M. TEALL

Dep. Med. Chem., Neurosci. Res. Cent., Merck Sharp and Dohme Res. Lab., Harlow, Essex CM20 2QR, UK

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J. MC KENNA,

J. MC KENNA

Dep. Med. Chem., Neurosci. Res. Cent., Merck Sharp and Dohme Res. Lab., Harlow, Essex CM20 2QR, UK

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T. HARRISON,

T. HARRISON

Dep. Med. Chem., Neurosci. Res. Cent., Merck Sharp and Dohme Res. Lab., Harlow, Essex CM20 2QR, UK

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C. J. SWAIN,

C. J. SWAIN

Dep. Med. Chem., Neurosci. Res. Cent., Merck Sharp and Dohme Res. Lab., Harlow, Essex CM20 2QR, UK

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M. A. CASCIERI,

M. A. CASCIERI

Dep. Med. Chem., Neurosci. Res. Cent., Merck Sharp and Dohme Res. Lab., Harlow, Essex CM20 2QR, UK

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S. SADOWSKI,

S. SADOWSKI

Dep. Med. Chem., Neurosci. Res. Cent., Merck Sharp and Dohme Res. Lab., Harlow, Essex CM20 2QR, UK

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C. STRADER,

C. STRADER

Dep. Med. Chem., Neurosci. Res. Cent., Merck Sharp and Dohme Res. Lab., Harlow, Essex CM20 2QR, UK

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R. BAKER,

R. BAKER

Dep. Med. Chem., Neurosci. Res. Cent., Merck Sharp and Dohme Res. Lab., Harlow, Essex CM20 2QR, UK

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First published: February 28, 1995

https://doi.org/10.1002/chin.199509215

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Abstract

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.

ChemInform Abstract

A number of 2-aminoethyl ethers, e.g. (I) and (II), based on diphenylalaninol, show significant affinity for the human NK1 receptor and reduced Ca2+ channel affinity, compared with quinuclidines related to CP 96,345.