ChemInform Abstract: Asymmetric Synthesis of N-(Ethoxycarbonyl)-β-methylphenylalanine Esters.
Abstract
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ChemInform Abstract
Silyl ketene acetals of (R)-3-phenylbutanoic acid such as (R)-(I), (V) or (VIII) containing different chiral auxiliary moieties are aminated by photolysis with N3-COOEt to give α-amino acid derivatives with 2 stereogenic centers in order to study the relative influence of the chiral auxiliaries with respect to the resident chirality. The diastereoselectivity seems to be affected more by the chirality of the ester moiety than by the resident chirality at the β-C atom.
