ChemInform Abstract: Diastereotopic Group Selective Intramolecular Conjugate Addition of 4-( 2-Hydroxyethyl)-p-quinol Derivatives: Synthesis of the Optically Pure cis-7-Oxabicyclo(4.3.0)non-2-en-4-one Skeleton.
Abstract
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ChemInform Abstract
The asymmetric syntheses of the optically pure oxabicyclononenone (-)-( Vc), which is a useful intermediate in the synthesis of optically active avermectins, and its enantiomer are carried out by cyclization of the p-quinol derivatives, first studied for the racemic compounds, such as (I) or (IV).