ChemInform Abstract: Tetrahydropyrido(2,1-b)quinazolin-11-ones and Tetrahydropyrido(1,2-a) quinazolin-6-ones via Thermal Cyclization of 2-Substituted 4(3H)- Quinazolinones.
Abstract
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ChemInform Abstract
Coupling of the anthranilic acids (I) with the 2-iminotetrahydrofuran ( II) forms the 2-substituted quinazolinones (III). These undergo thermal cyclization to give the regioisomeric tetrahydropyridoquinazolinones (IV) and (V) mentioned in the title.