ChemInform Abstract: Synthesis of Isocyanates from Carboxylic Acids Using Diphenylphosphoryl Azide and 1,8-Bis(dimethylamino)naphthalene.
Abstract
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ChemInform Abstract
Treatment of carboxylic acids such as (I) or (III) with diphenyl phosphorazidate and 1,8-bis(dimethylamino)naphthalene in THF leads to formation of highly pure isocyanates. The advantage of this method is based on the easy removal of the generated ammonium phosphate salt by precitipation. The results of the application of other amines and other solvents are described in the original paper; e.g., the use of dioxane as the solvent results in lower yields.
