Heterocyclic Compounds
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ChemInform Abstract: First Use of the Taylor Pteridine Synthesis as a Route to Polyglutamate Derivatives of Antifolates.
First published: October 1, 1991
Abstract
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ChemInform Abstract
Starting with the condensation reaction between the nitrobenzoyl derivative (I) of L-glutamate and di-tert-butyl L-glutamate (II), the pyrazine-substituted diglutamate (VI) is prepared. This reacts with acetamidine acetate (VII), performing a Taylor pteridine synthesis to give the tri-tert-butyl derivative (VIII) of 2-deamino-2- methylaminopterin diglutamate.
