ChemInform Abstract: Regiospecific Acylation Reactions of Imidazo(1,5-a)pyridine.
Abstract
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ChemInform Abstract
The imidazopyridine (I) is subjected to reaction with benzoyl chloride (II) under various conditions. Heating in xylenes or treatment with triethylamine/acetonitrile result in the formation of the salt (III) which is rearranged to give the 3-benzoyl derivative (IV). Friedel—Crafts acylation of (I) with (II), however, produces the 1-benzoylimidazopyridine (VI) via the intermediate salt (V). An isomerization process between (IV) and (VI) is not observed. The N-benzylimidazole (VII) is transformed into the 2-benzoylimidazole (VIII).