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ChemInform Abstract: Synthesis of Enantiomerically Pure Amino Acids Containing a 2-Amino-4- thiazolyl Side Chain.
First published: April 23, 1991
Abstract
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ChemInform Abstract
The aspartic or glutamic acid derivatives (I) are converted to the diazo ketones (V) via the mixed anhydrides (III). Degradation of (V) by treatment with hydrochloric acid gives the crude α-chloro ketones (VI) which undergo ring closure reaction with thiourea (VII), forming the protected thiazolyl-substituted amino acids (VIII).
