Volume 21, Issue 37
Natural Products
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ChemInform Abstract: The Synthesis of Hexahydro-6H-dibenzo(b,d)pyrans: Derivatives of 9-Nor-9β-hydroxyhexahydrocannabinol.

L. S. MELVIN

L. S. MELVIN

Cent. Res. Pfizer, Inc., Groton, CT 06340, USA

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J. BORDNER

J. BORDNER

Cent. Res. Pfizer, Inc., Groton, CT 06340, USA

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W. A. HADA

W. A. HADA

Cent. Res. Pfizer, Inc., Groton, CT 06340, USA

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M. R. JOHNSON

M. R. JOHNSON

Cent. Res. Pfizer, Inc., Groton, CT 06340, USA

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First published: September 11, 1990

Abstract

The biological activity of the title compounds, e.g. (IX), (XI) and (XVI), confirms that a phenolic -OH group (present in (XI)) is required for potent analgetic activity.

ChemInform Abstract

The biological activity of the title compounds, e.g. (IX), (XI) and (XVI), confirms that a phenolic -OH group (present in (XI)) is required for potent analgetic activity. (XI) is synthesized by a procedure which is similar to that described for the transformation of compound (V) to (IX).

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