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ChemInform Abstract: A Simple Preparation of S-Alkyl Homocysteine Derivatives: S-Phosphonomethyl Homocysteines as Inhibitors of Glutamine Synthetase.
First published: May 30, 1989
Abstract
Treatment of the bromophthalimidobutyrate (IV) with the thioloacetates (III) gives the 2-phthalimido-4-sulfenylbutyrates (V) which are saponified and N-deprotected, yielding the homocysteines (VI) or (VII).
ChemInform Abstract
Treatment of the bromophthalimidobutyrate (IV) with the thioloacetates (III) gives the 2-phthalimido-4-sulfenylbutyrates (V) which are saponified and N-deprotected, yielding the homocysteines (VI) or (VII). The phosphonomethyl derivative (VII) is oxidized, producing the sulfone (VIII) which is an inhibitor of glutamine synthetase.
