ChemInform Abstract: Total Synthesis of “Extended” Biliverdins: The Relation Between Their Conformation and Their Spectroscopic Properties.

ChemInform Abstract

Biliverdin (I) when treated with DBU affords biliverdin (II) of the neopterobilin type. The isomer with 3,8-chloroethyl substitution (i.e. exchange of methyl and chloroethyl groups in the A and B rings of (I)) also undergoes ring closure but with connection of pyrrole rings B-C instead of A-B as in (II). In a third isomer of (I) two ring closures takes place.