Preparative Organic Chemistry
Full Access
ChemInform Abstract: Asymmetric 1,4-Additions of Gilman Reagents to α,β-Disubstituted (E)-Enoylsultams/“Enolate” Protonations.
First published: May 30, 1989
Abstract
Asymmetric addition of the organocopper reagents (II) to the N-enoyl sultams (I) yields the products (III) as sole diastereomers with purities of ≥ 98% after crystallization of the initially obtained diastereomeric mixtures of crude products.
ChemInform Abstract
Asymmetric addition of the organocopper reagents (II) to the N-enoyl sultams (I) yields the products (III) as sole diastereomers with purities of ≥ 98% after crystallization of the initially obtained diastereomeric mixtures of crude products. Hydrolysis of (III) affords the enantiomerically pure carboxylic acids (IV) containing two new stereogenic centers.
