Volume 20, Issue 18
Natural Products
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ChemInform Abstract: Total Synthesis of Boromycin.

J. D. WHITE

J. D. WHITE

Dep. Chem., Oreg. State Univ., Corvallis, OR 97331, USA

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M. A. AVERY

M. A. AVERY

Dep. Chem., Oreg. State Univ., Corvallis, OR 97331, USA

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S. C. CHOUDHRY

S. C. CHOUDHRY

Dep. Chem., Oreg. State Univ., Corvallis, OR 97331, USA

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O. P. DHINGRA

O. P. DHINGRA

Dep. Chem., Oreg. State Univ., Corvallis, OR 97331, USA

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B. D. GRAY

B. D. GRAY

Dep. Chem., Oreg. State Univ., Corvallis, OR 97331, USA

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M. KANG

M. KANG

Dep. Chem., Oreg. State Univ., Corvallis, OR 97331, USA

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S. KUO

S. KUO

Dep. Chem., Oreg. State Univ., Corvallis, OR 97331, USA

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A. J. WHITTLE

A. J. WHITTLE

Dep. Chem., Oreg. State Univ., Corvallis, OR 97331, USA

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First published: May 2, 1989

Abstract

Coupling of the synthons (IV) and (VII) and subsequent work-up affords the boromycin precursor (IXa).

ChemInform Abstract

Coupling of the synthons (IV) and (VII) and subsequent work-up affords the boromycin precursor (IXa). The latter has already been converted to the title compound (IXb) by treatment with Boc-D-Val, followed by TFA. The reaction sequence starting from the lactone (I) constitutes the first total synthesis of boromycin.

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