Preparative Organic Chemistry
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ChemInform Abstract: Applications of Phase-Transfer Catalysis. Part 45. Enantioselective Phase-Transfer Catalysis by Optically Active Crown Ethers.
First published: May 2, 1989
Abstract
A series of 11 optically active crown ethers are probed as enantioselective phase-transfer catalysts in the epoxidation of unsaturated ketones by hypochlorite and in the addition of cyanide to these compounds.
ChemInform Abstract
A series of 11 optically active crown ethers are probed as enantioselective phase-transfer catalysts in the epoxidation of unsaturated ketones by hypochlorite and in the addition of cyanide to these compounds. Best results with up to 45% e.e. are obtained in the synthesis of the cyanide adduct (III). With various other substrates and catalysts, e.e. values of typically 7-17% are obtained.
