Heterocyclic Compounds
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ChemInform Abstract: Chemistry and Positive Inotropic Effect of Pelrinone and Related Derivatives. A Novel Class of 2-Methylpyrimidones as Inotropic Agents.
First published: August 16, 1988
Abstract
The preparation of a great number of pyrimidones such as (I) and pyrimidines such as (II) is described.
ChemInform Abstract
The preparation of a great number of pyrimidones such as (I) and pyrimidines such as (II) is described. The synthesis of the heterocyclic skeleton starts with ketene thioacetals or aminals. The inotropic and chronotropic effects of the compounds prepared are measured. The derivatives (Ia) and (Ic) prove to be the most potent ones.
