Heterocyclic Compounds
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ChemInform Abstract: Synthesis and Choleretic Activity of 3-(2-Aryl-5-R-benzimidazol-1-yl)butanoic Acids.
First published: January 12, 1988
Abstract
The o-chloronitrobenzenes (I) react with aminobutyric acid (II) to give the o-aminonitrobenzenes (III) which are reduced, yielding the o-phenylenediamines (IV).
ChemInform Abstract
The o-chloronitrobenzenes (I) react with aminobutyric acid (II) to give the o-aminonitrobenzenes (III) which are reduced, yielding the o-phenylenediamines (IV). Cyclocondensation of (IV) with the bisulfite adducts (V) produces the 3-benzimidazolylbutyric acids (VI). The acetyl derivatives (VIc) are reduced to form the α-hydroxyethylbenzimidazoles (VII). The acids (VI) and (VII) have choleretic activity.
