Volume 18, Issue 38
Natural Products
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ChemInform Abstract: Metallation of 3-Acetyltetramic Acids: A New Synthesis of 3-Dienoyl- and 3-Trienoyltetramic Acids.

R. C. F. JONES

R. C. F. JONES

Dep. Chem., Univ., Nottingham NG7 2RD, England

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A. D. BATES

A. D. BATES

Dep. Chem., Univ., Nottingham NG7 2RD, England

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First published: September 22, 1987

Abstract

The pyrrolidine-2,4-dione (I), prepared from L-valine, is deprotonated with butyllithium to form the trilithio derivative (II).

ChemInform Abstract

The pyrrolidine-2,4-dione (I), prepared from L-valine, is deprotonated with butyllithium to form the trilithio derivative (II). This reacts with the aldehydes (III), yielding the unsaturated tetramic acids (V).

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