Isocyclic Compounds
Full Access
ChemInform Abstract: Ritter Reactions. Part 2. Reductive Deamidation of N-Bridgehead Amides.
First published: September 22, 1987
Abstract
The diene (I) is cyclized on heating with sulfuric acid, acetic acid, and acetonitrile to form the amide (II).
ChemInform Abstract
The diene (I) is cyclized on heating with sulfuric acid, acetic acid, and acetonitrile to form the amide (II). Further heating in an acidic medium produces the deamidated compound (III) which is also obtained from (I) via the cyclization product (IV) and subsequent reduction. The acetamidoadamantanes (V) are cleaved with sulfuric acid and ethanol in the same manner, yielding the hydrocarbons (VI).
