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ChemInform Abstract: Synthesis of Guanine 7-Oxide, an Antitumor Antibiotic from Streptomyces Species.
First published: September 1, 1987
Abstract
Phenacyl bromide (I) is converted to the phenacylamines (III) which react with the pyrimidone (IV) to yield the N-disubstituted products (V).
ChemInform Abstract
Phenacyl bromide (I) is converted to the phenacylamines (III) which react with the pyrimidone (IV) to yield the N-disubstituted products (V). Basic treatment of (V) produces the guanine-N-oxides (VI). (VIf) is deblocked to form (VII) which is an antitumor agent, isolated from certain Streptomyces species. (UV-data).
