Organic Dyes
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ChemInform Abstract: Synthesis of Naphthoquinone Derivatives. Part 2. Synthesis of Shikalkin (.+-.)Shikonin and Related Compounds.
First published: June 16, 1987
Abstract
A three-step procedure leads from the naphthalenediol (I) to the aldehyde (III).
ChemInform Abstract
A three-step procedure leads from the naphthalenediol (I) to the aldehyde (III). This key intermediate undergoes side-chain introduction via a Grignard reaction and subsequent oxidation and demethylation reactions to give the title compound (XII). Similarly, the dihydroderivative (XIII) is prepared from (III).
