Heterocyclic Compounds
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ChemInform Abstract: Synthesis, Cell Growth Inhibition, and Antitumor Screening of 2-(p-nButylanilino)purines and Their Nucleoside Analogues.
First published: June 16, 1987
Abstract
The anilinopurines (II) and their deoxyribofuranosyl derivatives (IV) and (V) are synthesized as outlined in the reaction scheme.
ChemInform Abstract
The anilinopurines (II) and their deoxyribofuranosyl derivatives (IV) and (V) are synthesized as outlined in the reaction scheme. Moreover, the p-butylanilinochloropurine (IIa) is transformed into the hydroxyethoxymethyl derivatives (VI) and (VII). The compounds synthesized are evaluated as inhibitors of DNA polymerase α and tested for antitumor activity in vivo against P388 leukemia. Their effects on cell growth and on macromolecular synthesis are also studied. (UV-, 1H-NMR-data).
