ChemInform Abstract: Substituted (Aryloxy)alkanoic Acids as Antagonists of Slow-Reacting Substance of Anaphylaxis.
Abstract
Reaction of the dihydroxyacetophenone (I) with the bromoalkanoic acid esters (II) and subsequently with the dibromo compounds (III) yields the bromides (IV), which are coupled with (I) to give the esters (Va).
ChemInform Abstract
Reaction of the dihydroxyacetophenone (I) with the bromoalkanoic acid esters (II) and subsequently with the dibromo compounds (III) yields the bromides (IV), which are coupled with (I) to give the esters (Va). Hydrolysis of (Va) affords the acids (Vb). The naphthalene derivatives (VII) are prepared from the dihydroxynaphthalene (VI) in a similar manner. The aryloxyalkanoic acids (Vb) and (VII) areevaluated as antagonists of SRS-A-induced contractions of guinea pig ileum and as inhibitors of LTE-induced bronchoconstriction in guinea pigs.
