Fuel filters are necessary to prevent damage of the high-pressure fuel injection system caused by particles and water. The standard for measuring the particle retention efficiency of these filters is the ISO 19438 from 2003. The test conditions lead to reproducible results so that filter systems can be compared to each other. However, transient flow, vibration, and real field fuel affect the filtration efficiency significantly. To take real-life conditions into the test labs, the ISO 19612 is currently in work. The article provides comparisons of the filtration performance for similar filter systems with simulated real-life conditions on different test rigs, including a novel test rig considering all parameters that are discussed within the ISO 19612 working group.